With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36193-65-4,1H-Indole-2-carbonitrile,as a common compound, the synthetic route is as follows.
General procedure: Cyanoindole 6 (40 mg, 0.256 mmol, 1 equiv.), Mn(OAc)3.2H2O (345 mg, 1.29 mmol, 5 equiv),and diethyl malonate (205 mg, 1.28 mmol, 5 equiv) were dissolved in aceticacid (10 mL) and heated to reflux for 2 h. After TLC indicated complete consumption of the starting indole, the reaction was poured into water (200 mL) and extracted with ethyl acetate (3 50 mL). The combined organic extracts were washed with water (3 100 mL), brine (1 100 mL), dried over sodium sulfate, filtered, and concentrated in vacuo to give a brown oil. The product was purified via flash chromatography (silica gel, hexanes:EtOAc 4:1)to afford 15 as a white solid (90%);20
36193-65-4 1H-Indole-2-carbonitrile 3787599, aindole-building-block compound, is more and more widely used in various.
Reference£º
Article; Lopchuk, Justin M.; Montgomery, William L.; Jasinski, Jerry P.; Gorjifard, Sayeh; Gribble, Gordon W.; Tetrahedron Letters; vol. 54; 45; (2013); p. 6142 – 6145;,
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