With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6245-89-2,(1H-Indol-3-yl)-1-propanamine,as a common compound, the synthetic route is as follows.
General procedure: The carboxylic acid (1.0?equiv) and the amine (1.0?1.1?equiv) were dissolved in CH2Cl2 (3?4?mL/mmol) and treated with N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDC) (1.1?equiv), 1-hydroxybenzotriazole hydrate (HOBt) (1.1?equiv), and Et3N (2.4?equiv or 3.4?equiv for amine hydrochlorides) and stirred at rt overnight. If the reaction was heterogeneous, DMF was added until homogeneity was obtained. The reaction mixture was washed with water, 10percent aq HCl solution, and satd aq NaHCO3 solution then dried over anhydrous sodium sulfate and concentrated under reduced pressure.
The synthetic route of 6245-89-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Goff, Dane A.; Tetrahedron; vol. 69; 1; (2013); p. 242 – 256;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles