With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-34-9,5-Bromo-2-methylindole,as a common compound, the synthetic route is as follows.
General procedure: 2-Methyl-1H-indole derivatives (0.5-6 mmol, 1 equiv) were stirred at 80 C in acetic acid (2 mL/1 mmol), 4-piperidone hydrochloride hydrate (1.5-18 mmol, 3 equiv) and 1 M phosphoric acid (1 mL/1 mmol) were added. After 1-2 h, the mixture was poured into ice/ammonia, and extracted with ethyl acetate (3 x 25 mL). The combined organic layers were washed with water and brine, dried, and evaporated in vacuo to give the title compounds. The crude products were purified by silica gel column chromatography (ethylacetate-methanol, gradient) and most of them were converted to the corresponding salts by dissolving the free base in methanol or ethanol and adding one equivalent of oxalic acid or ethanolic HCl solution. The solvent was removed and azeotroped with absolute ethanol in vacuo followed by recrystallization from appropriate solvents.
1075-34-9 5-Bromo-2-methylindole 5003968, aindole-building-block compound, is more and more widely used in various.
Reference£º
Article; Mattsson, Cecilia; Svensson, Peder; Boettcher, Henning; Sonesson, Clas; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 578 – 588;,
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