In an article, author is Moradi, Tahereh, once mentioned the application of 13311-84-7, Name is Flutamide, molecular formula is C11H11F3N2O3, molecular weight is 276.2119, MDL number is MFCD00072009, category is indole-building-block. Now introduce a scientific discovery about this category, COA of Formula: C11H11F3N2O3.
Perfluoropyridylation of indoles via reaction of perfluorinated pyridines with indole compounds
The reaction of perfluoropyridines with indoles and bis(indolyl)methanes (BIMs) was investigated. The aromatic nucleophilic substitution of pentafluoropyridine with indoles occurs at the 4-position of pyridine ring by nitrogen site of indolyl anion, while reaction with 2,3,5,6-tetrafluoro-4-(phenylsulfonyl)pyridine gave a mixture of products arising substitution at 2-position of pyridine ring and replacement of phenylsulfonyl group. Furthermore, the reaction of pentafluoropyridine with BIMs yielded mixture of mono- and bis-perfluoropyridyl products. [GRAPHICS] .
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles