In an article, author is Anastasiou, Ioannis, once mentioned the application of 490-91-5, Product Details of 490-91-5, Name is Thymoquinone, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00001602, category is indole-building-block. Now introduce a scientific discovery about this category.
C2-H Arylation of Indoles Catalyzed by Palladium-Containing Metal-Organic-Framework in gamma-Valerolactone
An efficient and selective procedure was developed for the direct C2-H arylation of indoles using a Pd-loaded metal-organic framework (MOF) as a heterogeneous catalyst and the nontoxic biomass-derived solvent gamma-valerolactone (GVL) as a reaction medium. The developed method allows for excellent yields and C-2 selectivity to be achieved and tolerates various substituents on the indole scaffold. The established conditions ensure the stability of the catalyst as well as recoverability, reusability, and low metal leaching into the solution.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles