Downstream synthetic route of 868656-97-7

As the paragraph descriping shows that 868656-97-7 is playing an increasingly important role.

868656-97-7, Methyl 6-bromo-1H-indole-3-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

868656-97-7, Preparation 40 6-(4-Hydroxy-2-methyl-phenyl)-lH-indole-3-carboxylic acid methyl esterA mixture of 3-methyl-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenol (213 mg, 0.910 mmol), -bromo-lH-indole-S-carboxylic acid methyl ester (193 mg, 0.759 mmol), tetrakis(triphenylphosphine)palladium(0) (57 mg, 0.046 mmol), DMF (2.7 mL), ethanol (1.34 mL) and 2M aqueous potassium carbonate (1.34 mL) is heated to 100 0C for 60 hours. The reaction is cooled to room temperature, diluted with water and acidified with 1 N HCl. The resulting solution is extracted with ethyl acetate. The combined organic layers are dried over anhydrous magnesium sulfate and concentrated. The residue is purified with flash chromatography eluting with 25to 40 % ethyl acetate/heptane to give the title compound (134 mg, 63%). ES/MS m/e 280.3 (M-I).

As the paragraph descriping shows that 868656-97-7 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/140183; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles