With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103858-52-2,Ethyl 4-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
Ethyl 4-bromo-1H-indole-2-carboxylate 9 (268.11 mg, 1.00 mmol, 1.0 eq), (2-ethylphenyl)boronic acid (224.97 mg, 1.50 mmol, 1.5 eq), Pd(PPh3)4 (57.79 mg, 0.05 mmol, 0.05 eq) and Na2CO3 (211.98 mg, 2.00 mmol, 2.0 eq) were dissolved in 15 mL of toluene, EtOH and H2O (10:3:2, v/v/v). The reaction mixture was purged with N2 and heated to reflux overnight. The reaction mixture was then filtered through Celite, washed with 20 mL H2O, dried with MgSO4, and purified by column chromatography (EtOAc:Heptane = 1:10, v/v) to afford ethyl 4-(2-ethylphenyl)-1H-indole-2-carboxylate 15. Yield: 92.9%. 1H NMR (400 MHz, Methanol-d4) delta 7.35 (d, J = 8.3 Hz, 1H), 7.29 – 7.18 (m, 3H), 7.17 – 7.07 (m, 2H), 6.84 (d, J = 6.8 Hz, 1H), 6.63 (s, 1H), 4.24 (q, J = 7.1 Hz, 2H), 2.39 (s, 2H), 1.26 (t, J = 7.1 Hz, 3H), 0.86 (t, J = 7.5 Hz, 3H).13C NMR (151 MHz, Methanol-d4) delta 162.0, 142.0, 139.5, 137.5, 135.8, 129.7, 128.2, 127.4, 127.3, 127.0, 125.0, 124.3, 120.4, 110.7, 107.2, 60.4, 26.0, 14.8, 13.2., 103858-52-2
Big data shows that 103858-52-2 is playing an increasingly important role.
Reference£º
Article; Clausen, Rasmus P.; Hansen, Kasper B.; Rouzbeh, Nirvan; Zhao, Fabao; Tetrahedron Letters; (2020);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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