Let’s face it, organic chemistry can seem difficult to learn, Formula: https://www.ambeed.com/products/86-95-3.html, Especially from a beginner’s point of view. Like 86-95-3, Name is 4-Hydroxyquinolin-2(1H)-one, molecular formula is indole-building-block, belongs to indole-building-block compound. In a document, author is Green, Ilene L., introducing its new discovery.
The synthesis of the indole sunscreen pigment prenostodione was attempted via an LDA-initiated condensation of N-carbamate indole-2-methyl ester 22 with 4-[(t-butyldimethylsilyl)oxy]benzaldehyde (14) and a late-stage Vilsmeier-Haack formylation. Difficulties with the ensuing oxidation required installation of a C-3 carboxylic acid necessitating the use of a recently reported protocol and thus a formal synthesis of the natural product was realized from 2-aminobenzyl alcohol (17) in nine steps. [GRAPHICS] .
If you are hungry for even more, make sure to check my other article about 86-95-3, Formula: https://www.ambeed.com/products/86-95-3.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles