15861-24-2, Indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-cyano indole (100 g) in dichloromethane (4 L) titanium tetrachloride (214 g) was added at 0-5 C. under nitrogen atmosphere. The resulting mixture was stirred for 45 minutes and then 4-chlorobutyryl chloride (168.8 g) was added to the mixture drop wise. The reaction mass was stirred at room temperature for 5 hours and again cooled to 0-5 C. The reaction mass is quenched by ice-cold water (2 L) and stirred for 4 hours. The resulting solid material was filtered, washed with water (300 mL). Water (1 L) was added to the wet material and the pH of the reaction mass was adjusted to 7.0 with aqueous solution of sodium bicarbonate (3% w/v). The reaction mass was stirred for 10-15 minutes at room temperature, filtered, washed with water and dried to provide the desired compound. [0506] Yield: 120 g (69%) [0507] Purity (by HPLC): 91.96%., 15861-24-2
15861-24-2 Indole-5-carbonitrile 27513, aindole-building-block compound, is more and more widely used in various.
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Patent; Iqbal, Javed; Oruganti, Srinivas; Rapolu, Rajesh Kumar; Peddy, Vishweshwar; Boge, Rajesham; Pathivada, Deepika; Velaga, Dharma Jagannadha Rao; Yarraguntla, Sesha Reddy; Baddam, Sudhakar Reddy; Naredla, Anitha; Doniparthi, Kiran Kumar; Nadgoud, Ramesh Kumar; Pagadala, Narasimha Rao; Unniaran, Syam Kumar; Ramakrishnan, Srividya; US2015/126525; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles