With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.
A mixture of 4-nitroindole (15 grams, 92.5 mmol), iron powder (25.92 grams, 462.9 mmol), concentrated hydrochloric acid (5 mL) and water (50 mL) in ethanol (150 mL) was refluxed at 90 0C and the progress of the reaction was monitored by thin layer chromatography. After completion of the reaction (2 hours), the reaction mixture was filtered through hy-flow bed and the filtrate was concentrated under reduced pressure. The residual mass was diluted with ice water (500 mL), basified with aqueous sodium hydroxide solution to pH 9 – 10 and extracted with ethyl acetate (2.x 250 mL). The combined organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product (13.2 grams), thus obtained, was purified by column chromatography using silica-gel (100 – 200 mesh), the eluent system being ethyl acetate and n-hexane (1:9) to obtain 12.13 grams of title product. Melting Range: 101.7 – 106.8 0C; I.R (cm-‘): 1109, 1519, 2931, 3325, 3394, 3440;1H-NMR (ppm): 3.92 (2H, bs), 6.40 – 6.42 (IH, m), 6.46 – 6.47 (IH, m), 6.86 – 6.88 (IH; d, J = 8.14 Hz), 6.99 – 7.03 (IH, t, J = 7.8 Hz), 7.11 – 7.12 (IH, t, 2.8 Hz), 8.11 (IH, bs); Mass (m/z): 133.15 (M+H) +
4769-97-5, As the paragraph descriping shows that 4769-97-5 is playing an increasingly important role.
Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; WO2009/34581; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles