In an article, author is Poloznikov, A. A., once mentioned the application of 65-46-3, COA of Formula: https://www.ambeed.com/products/65-46-3.html, Name is Cytidine, molecular formula is C9H13N3O5, molecular weight is 243.2166, MDL number is MFCD00006545, category is indole-building-block. Now introduce a scientific discovery about this category.
The effect of indole-3-carbinol on the proliferation and migration of MDA-MB-231 breast-cancer cells and healthy MCF-10A breast-tissue cells has been studied. It was shown that indole-3-carbinol reliably reduced the proliferation and migration of MDA-MB-231 cells and does not significantly affect MCF-10A cells. The incubation of MDA-MB-231 tumor cells with 100 mu M indole-3-carbinol for 48 h resulted in a marked decrease in the expression of the Wnt cascade genes CCND1 (by 28%), Sp1 (by 44%), CDK6 (by 47%), as well as the EGFR and FASN genes (by 64 and 22%, respectively). Incubation of the MCF-10A cell line under the same conditions induced a noticeable decrease in the expression of only two genes, EGFR (by 16%) and CDK6 (by 9%). Indole-3-carbinol was also shown to display selective DNA demethylating activity in breast-tumor cells and to reverse the process of abnormal methylation and functional blockage of the antitumor WIF-1 gene. The obtained data indicate that drugs containing indole-3-carbinol as an active component can be potential regulators of epigenetic processes in the complex treatment of breast cancer and other tumors.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles