With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252978-89-5,tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 13 1-[(2,5-Dichloro-3-thienyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride (Scheme 1) The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,5-dichloro-3-thienylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) delta 9.24 (br, 1H), 7.78 (d, J=5 Hz, 1H), 7.72 (s, 1H), 7.57 (d, J=8 Hz, 1H), 7.29 (t, J=8 Hz, 1H), 7.01 (d, J=5 Hz, 1H), 6.86 (d, J=8 Hz, 1H), 3.31 (m, 8H). MS (ESI+) for m/z 416 (M+H)+., 252978-89-5
Big data shows that 252978-89-5 is playing an increasingly important role.
Reference£º
Patent; Caldirola, Patrizia; Nilsson, Bjorn M.; Johansson, Gary; US2002/165251; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles