Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Quality Control of: Indole-5-carbonitrile, Which mentioned a new discovery about 15861-24-2
A copper-catalyzed intermolecular oxidative homocoupling of indoles has been developed for the direct construction of valuable C3-C3 biindolyl scaffolds. Using this protocol, 3,3?-bisindolin-2-ones are obtained in good yields and with excellent chemo-and regioselectivity. The methodology shows good functional group tolerance, allows the use of easily available inexpensive precursors, has simple operation, and can be performed under mild reaction conditions. From a retrosynthetic point of view, the strategic formation of a C-C bond via C(sp3-H)/C(sp2-H) dehydrogenative coupling may be useful in indole-derived pharmaceuticals and natural products. Upon screening HepG-2, SCG-7901, MDA-MB-468, MDA-MB-435 and Ishikawa cancer cell lines, compound 2s exhibited a good inhibitory effect against HepG-2 at 10.49 ± 0.41 muM in vitro antitumor activities. Further studies, involving apoptosis ratio detection and cell cycle analysis, were conducted on compound 2s.
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles