With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.
52488-36-5, General procedure: Phosphorus oxychloride (2.3 mL, 24.0 mmol) was added to ice-cold, stirred, dry dimethylformamide (7.8 mL, 99.0 mmol) followed by dry pyridine (2.0 mL, 26.0 mmol). A solution of the foregoing protected indole-4-methanol 33 (8.50 g, 22.0 mmol) in dimethylformamide (3 mL) was then added dropwise and the resulting solution warmed to 35 C for 0.75 h before being poured onto ice. Sodium hydroxide (4.00 g) in water (200 mL) was added in portions and the resulting mixture boiled for 2 min then cooled and extracted with dichloromethane (3¡Á50 mL). The combined extracts were dried, filtered and evaporated to give the indole-3-carboxaldehyde35 (7.52 g, 82%) as a brown oil
As the paragraph descriping shows that 52488-36-5 is playing an increasingly important role.
Reference£º
Article; Griffiths-Jones, Charlotte M.; Knight, David W.; Tetrahedron; vol. 67; 44; (2011); p. 8515 – 8528;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles