With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
General procedure: A solution of the xanthate 3 (1.37 g, 4.87 mmol) and the corresponding indole (4a-4g) (0.353 g, 2.21 mmol) in degassed 1,2-dichloroethane (DCE) (9 mL) was heated at reflux, and dilauroyl peroxide (DLP) (2.21 g, 5.54 mmol) in solid form was added in several portions (0.92 mmol/h). The reaction was monitored by TLC and was stopped after 6 h. The solvent was removed under reduced pressure, and the crude residues were extracted with acetonitrile and washed with hexane. The polar phase was then concentrated under reduced pressure and purified by chromatography on a silica gel column using hexane-ethyl acetate as the eluent to obtain the desired products., 2338-71-8
Big data shows that 2338-71-8 is playing an increasingly important role.
Reference£º
Article; Canche Chay, Cristina I.; Cansino, Rocio Gomez; Espitia Pinzon, Clara I.; Torres-Ochoa, Ruben O.; Martinez, Roberto; Marine Drugs; vol. 12; 4; (2014); p. 1757 – 1772;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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