387-44-0, 7-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Quinoline moiety – General Procedure Q In microwave vessel, quinoline (2.oeq) and indole (i.oeq) were mixed together and the system was sealed and placed under nitrogen, after a purge with vacuum/N2 (3 times). Then, HC1 solution 4 M in 1,4-dioxane (i.2eq) was added with the needle immersed in the mixture (exothermic reaction). The reaction mixture was heated with microwave during 2 h at 160 C. The reaction mixture was taken up with a minimum of MeOH and when the residue was dissolved, it was transferred in mixture of AcOEt and saturated NaHC03 solution. The resulting solution was extracted and the aqueous phase was washed with AcOEt (x2). The organic layers were combined, washed with o.oi M critic acid solution, saturated NaHC03 solution, dried over Na2S04 and concentrated to dryness under reduced pressure. Finally, the crude was purified by automated combi-flash to afford the good compound., 387-44-0
387-44-0 7-Fluoroindole 2774504, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; THE UNIVERSITY OF BRITISH COLUMBIA; SIMON FRASER UNIVERSITY; RENNIE, Paul; TCHERKASSOV, Artem; YOUNG, Robert, N.; ANDRE, Christophe, M.; WO2015/154169; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles