Lin, RH; Mitchell, S; Netscher, T; Medlock, J; Stemmler, RT; Bonrath, W; Letinois, U; Perez-Ramirez, J in [Lin, Ronghe; Mitchell, Sharon; Perez-Ramirez, Javier] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Inst Chem & Bioengn, Vladimir Prelog Weg 1, CH-8093 Zurich, Switzerland; [Netscher, Thomas; Medlock, Jonathan; Stemmler, Rene T.; Bonrath, Werner; Letinois, Ulla] DSM Nutr Prod Res & Dev, POB 2676, CH-4002 Basel, Switzerland published Substrate substitution effects in the Fries rearrangement of aryl esters over zeolite catalysts in 2020.0, Cited 38.0. Safety of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
The catalytic transformation of aryl esters to hydroxyacetophenonesviaFries rearrangement over solid acids is of interest to avoid the use of corrosive and toxic Lewis and Bronsted acids traditionally applied. Microporous zeolites are known to catalyze the reaction of simple substrates such as phenyl acetate, but their application to substituted derivatives has received limited attention. To refine structure-activity relationships, here we examine the impact of various parameters including the solvent polarity, water content, acidic properties, and framework type on the reaction scheme in the Fries rearrangement ofp-tolyl acetate over common solid acids. The results confirm the importance of providing a high concentration of accessible Bronsted acid sites, with beta zeolites exhibiting the best performance. Extension of the substrate scope by substituting methyl groups in multiple positions identifies a framework-dependent effect on the rearrangement chemistry and highlights the potential for the transformation of dimethylphenyl acetates. Kinetic studies show that the major competitive path of cleavage of the ester C-O bond usually occurs in parallel to the Fries rearrangement. The possibility of sequentially acylating the resulting phenol depends on the substrate and reaction conditions.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Lin, RH; Mitchell, S; Netscher, T; Medlock, J; Stemmler, RT; Bonrath, W; Letinois, U; Perez-Ramirez, J or concate me.. Safety of 4′-Hydroxyacetophenone
Reference:
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles