With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-57-3,Ethyl 5-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
5-Nitro-1 H-indole-2-carboxylic acid ethyl ester (14.9 mmol) was suspended in acetone(50 ml) and added to a mixture of titanium(lll) chloride (91ml, >10% in 2M hydrochloric acid) and ammonium acetate (265ml, 4M). The reaction was stirred for 2h and neutralized with saturated sodium hydrogen carbonate. The mixture was extracted with ethyl acetate (100ml) and the organic layer dried (MgSO4). The solvent was removed in vacuo to give a light brown solid which was purified by silica chromatography to give the title compound as an off-white solid (1.57g) m/z = 205 in MS ES+.
16732-57-3, As the paragraph descriping shows that 16732-57-3 is playing an increasingly important role.
Reference£º
Patent; MEDIVIR AB; WO2007/6714; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles