1953-54-4, 5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of [NAOH] (720 mg, 18 mmol) and acetone/water 1: 1 (72 ml), 4,6- dichloropyrimidine (2.4 g, [18 MMOL)] and 5-hydroxy-indole (2.68 g, 18 [MMOL)] are added. After stirring for 70 min at 65 [C,] the brownish solution is cooled to rt and diluted with AcOEt and water. The aqueous layer is separated off and extracted twice with AcOEt. The organic layers are washed with water, saturated Na2CO3 solution, water and brine, dried [(NA2SO4)] and concentrated. The crude product can be used without further purification: m. p.: 137-138 [C] ; MS: [[M+1] += 246.]
1953-54-4, As the paragraph descriping shows that 1953-54-4 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/99771; (2003); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles