Formula: C7H8O. In 2019.0 J APPL SPECTROSC+ published article about SOLUBILITY; POLYSORBATE-80; DISSOLUTION; FORMULATION; BEHAVIOR in [Leontiev, V. N.; Lazovskaya, O. I.] Belarusian State Technol Univ, 13a Sverdlov Str, Minsk 220006, BELARUS in 2019.0, Cited 15.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
The stability of micellar solutions of amiodarone hydrochloride in the presence of polysorbate-80 and benzyl alcohol was studied using fluorescence spectrometry with lambda(ex) = 420 m and lambda(em) = 506 nm. A formation scheme for mixed micelles consisting of nonionizable surfactant polysorbate-80 and cationic amiodarone with chloride counterion was proposed. Benzyl alcohol was found to lower the stability of the mixed micelles and lead to crystallization o f amiodarone hydrochloride. The counterion was replaced in the presence of acetate so that crystals of amiodarone acetate with a characteristic band for acetate carbonyl stretching vibrations v(C=O) at 1734 cm(-1) were formed. The solubilities of amiodarone hydrochloride and acetate in H2O at 20 degrees C were determined to be 0.33 and 0.058 mg/mL. A change of the amiodarone hydrochloride to polysorbate-80 mole ratio and avoidance of benzyl alcohol and acetate-containing solutions are recommended to improve the stability of the parenteral dosage form.
Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Leontiev, VN; Lazovskaya, OI or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles