With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-44-0,7-Fluoroindole,as a common compound, the synthetic route is as follows.
EXAMPLE 18 7-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Beginning with 2.0 gm (14.8 mMol) 7-fluoro-1H-indole and 4.6 gm (30.0 mMol) 4-piperidone hydrochloride monohydrate, 2.1 gm (66%) of the title compound were recovered as a white solid. m.p.=186-188 C. MS(FD): m/e=216 (M+) EA: Calculated for: C13 H13 N2 F: Theory: C, 72.20; H, 6.06; N, 12.95. Found: C, 72.41; H, 6.24; N, 13.09.
387-44-0, The synthetic route of 387-44-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Eli Lilly and Company; US5846982; (1998); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles