I found the field of Pharmacology & Pharmacy very interesting. Saw the article Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase published in 2019.0. HPLC of Formula: C7H6O2, Reprint Addresses Kumar, V (corresponding author), Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Lab Organ & Med Chem, Bathinda 151001, Punjab, India.; Parkash, J (corresponding author), Cent Univ Punjab, Sch Basic & Appl Sci, Dept Anim Sci, Bathinda, Punjab, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde
Alzheimer’s disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years’ different pharmacological strategies including multi-targeting agents are being explored for the effective drug development for AD. A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. All the compounds were found to be selective and reversible inhibitors of MAO-B isoform. These compounds also displayed good AChE inhibition potential with IC50 values in low micromolar range. AVB4 was found to be the most potent MAO-B inhibitor with IC50 value of 1.49 +/- 0.09 mu M and AVB1 was found to be the most potent AChE inhibitor with IC50 value of 135 +/- 0.03 mu M. In the ROS protection inhibition studies, AVB1 and AVB4 displayed weak but interesting activity in SH-SYSY cells. In the cytotoxicity studies involving SH-SY5Y cells, both AVB1 and AVB4 were found to be non-toxic to the tissue cells. In the molecular dynamic simulation studies of 30 ns, the potent compounds were found to be quite stable in the active site of MAO-B and AChE. The results suggested that AVB1 and AVB4 are promising dual inhibitors and have the potential to be developed as anti-Alzheimer’s drug. (C) 2019 Published by Elsevier Masson SAS.
HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles