Recently I am researching about GLUCOSIDASE INHIBITORS; BIOLOGICAL EVALUATION; IN-SILICO; ANALOGS, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Taha, M; Rahim, F; Zaman, K; Selvaraj, M; Uddin, N; Farooq, RK; Nawaz, M; Sajid, M; Nawaz, F; Ibrahim, M; Khan, KM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Product Details of 100-83-4
A series of twenty-six analogs of benzimidazole based oxadiazole have been synthesized and evaluated against alpha-glycosidase enzyme. Most the analogs showed excellent to good inhibitory potential. Among the screened analogs, analog 1, 2, 3 and 14 with IC50 values 4.6 +/- 0.1, 9.50 +/- 0.3, 2.6 +/- 0.1 and 9.30 +/- 0.4 mu M respectively showedexcellent inhibitory potential than reference drug acarbose (IC50 = 38.45 +/- 0.80 mu M). Some of the analogs like 19, 21, 22 and 23 with methyl and methoxy substituent on phenyl ring show hydrophobic interaction and were found with no inhibitory potential. The binding interactions between synthesized analogs and ligands protein were confirmed through molecular docking study. Various spectroscopic techniques like H-1 NMR, C-13 NMR, and EI-MS were used for characterization of all synthesized analogs. These derivatives were synthesized by simple mode of synthesis like heterocyclic ring formation.
Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Taha, M; Rahim, F; Zaman, K; Selvaraj, M; Uddin, N; Farooq, RK; Nawaz, M; Sajid, M; Nawaz, F; Ibrahim, M; Khan, KM or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles