Computed Properties of C8H8O2. In 2019.0 CAN J CHEM published article about PHASE S(N)2 REACTIONS; NUCLEOPHILIC-SUBSTITUTION REACTIONS; S-4-NITROPHENYL 4-SUBSTITUTED THIOBENZOATES; ELECTROPHILIC PHOSPHORUS CENTERS; P-NITROPHENYL ACETATE; GROUND-STATE; CONTRASTING REACTIVITY; MICROSOLVATED ANIONS; ENHANCED REACTIVITY; DIMETHYL-SULFOXIDE in [Um, Ik-Hwan; Bae, Ae-Ri] Ewha Womans Univ, Dept Chem, Seoul 03767, South Korea; [Dust, Julian M.] Grenfell Campus Mem Univ Newfoundland, Dept Chem, Corner Brook, NF A2H 5G4, Canada; [Dust, Julian M.] Grenfell Campus Mem Univ Newfoundland, Dept Environm Sci, Corner Brook, NF A2H 5G4, Canada in 2019.0, Cited 75.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
A kinetic study is reported for nucleophilic substitution reactions of Y-substituted-phenyl cinnamates (1a-1h) with a series of primary amines including hydrazine in H2O containing 20 mol % DMSO at 25.0 degrees C. The Bronsted-type plot for the reaction of 2,4-dinitrophenyl cinnamate (1a) is linear with beta(nuc) = 0.57 except hydrazine, which exhibits positive deviation from the linear correlation (i.e., the alpha-effect). The Bronsted-type plots for the reactions of 1a-1h with hydrazine and glycylglycine (glygly) are also linear with beta(1g) = -0.71 and -0.87, respectively, when 1a is excluded from the linear correlation. Thus, the reactions have been concluded to proceed through a concerted mechanism on the basis of the linear Bronsted-type plots and magnitudes of the beta(nuc) and beta(1g) values. The alpha-effect shown by hydrazine is dependent on electronic nature of the substituent Y in the leaving group, e.g., it increases as the substituent Y becomes a weaker electron-withdrawing group (or as basicity of the leaving aryloxide increases), indicating that the alpha-effect is not due to destabilization of the ground state but mainly due to stabilization of the transition state. A five-membered cyclic TS structure, which could increase nucleofugality of the leaving aryloxide through H-bonding interaction, has been proposed to account for the leaving-group dependent alpha-effect found in this study. The theories suggested previously to rationalize the alpha-effect found for the related systems are also discussed.
Computed Properties of C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Um, IH; Bae, AR; Dust, JM or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles