Bakholdina, LA; Markova, AA; Khlebnikov, AI; Sevodin, VP in [Bakholdina, L. A.; Sevodin, V. P.] II Polzunov Altai State Tech Univ, Biisk Technol Inst Filial, 27 Trofimov St, Biisk 659305, Altai Krai, Russia; [Bakholdina, L. A.] Russian Acad Sci, Inst Problems Chem & Energet Technol, Siberian Branch, Biisk 659322, Altai Krai, Russia; [Markova, A. A.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia; [Khlebnikov, A., I] Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia published Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells in 2019.0, Cited 19.0. Safety of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
A series of esters of ferulic acid and alcohols were synthesized and characterized structurally. All tested synthetic compounds were more cytotoxic against HCT116 cell line (human colon carcinoma) than ferulic acid. Benzyl and phenylethyl esters of ferulic acid were the most active compounds (IC50 = 0.0077 and 0.0065 g/L, respectively). Feruloylated wheat-bran oligosaccharides were less active than free ferulic acid against HCT116 tumor cells.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles