An article Synthesis and antitussive activity of obtucarbamate A derivatives WOS:000535085600001 published article about EXPECTORANT; COUGH in [Ma, Xiaoyun; Liang, Zhiyuan; Gan, Xiuhai] Guizhou Educ Univ, Sch Chem & Mat Sci, Guiyang, Peoples R China; [Wei, Gang] CSIRO Mineral Resources, Lindfield, NSW, Australia; [Zhou, Qingdi] Univ Sydney, Sch Chem, Sydney, NSW, Australia in 2020.0, Cited 16.0. Application In Synthesis of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1% using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 degrees C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles