An article Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling WOS:000554891400004 published article about PHOSPHORYLATION CASCADE; HYPERTENSION; COTRANSPORTER; MUTATIONS in [Fujii, Shinya; Watanabe, Yuko; Suzuyama, Honoka; Ishigami-Yuasa, Mari; Kagechika, Hiroyuki] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan; [Kikuchi, Eriko; Mori, Takayasu; Isobe, Kiyoshi; Uchida, Shinichi] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan in 2020, Cited 18. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Category: indole-building-block
We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/ SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.
About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H or concate me.. Category: indole-building-block
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles