An article Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones WOS:000504587900001 published article about ENTAMOEBA-HISTOLYTICA; BINDING-SITE; GIARDIA; TUBULIN; DERIVATIVES; RESISTANCE; MECHANISMS; INHIBITORS; DISEASE in [Caceres-Castillo, David; Carballo, Ruben M.; Quijano-Quinones, Ramiro; Miron-Lopez, Gumersindo; Graniel-Sabido, Manlio; Mena-Rejon, Gonzalo J.] Univ Autonoma Yucatan, Fac Quim, C 43 613, Merida 97069, Yucatan, Mexico; [Moo-Puc, Rosa E.] Ctr Med Ignacio Garcia Tellez, Unidad Med Alta Especialidad, Unidad Invest Med Yucatan, IMSS, C 41,439, Merida 97150, Yucatan, Mexico in 2020.0, Cited 29.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were synthesized using microwave-assisted Claissen-Smichdt condensation and evaluated for their activity against Giardia lamblia and Green monkey kidney cells. Five compounds exhibited activity against G. lamblia at IC50’s 3m exhibited the highest antigiardial activity (IC50 = 1.03 mu M), even more than the positive control (metronidazole, IC50 = 1.4 mu M), and selectivity (SI = 38.9). A preliminary SAR study suggested that electrophylicity has not relationship with antigiardiasic activity, and the docking study reveals that synthesized chalcones bind at zone 3 of colchicine site, therefore presumably the action mechanism of the synthesized chalcones does not follow the Michael acceptor mechanism.
Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Caceres-Castillo, D; Carballo, RM; Quijano-Quinones, R; Miron-Lopez, G; Graniel-Sabido, M; Moo-Puc, RE; Mena-Rejon, GJ or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles