I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents published in 2019. COA of Formula: C8H8O2, Reprint Addresses Sun, J; Wang, XJ (corresponding author), Shandong Acad Med Sci, Inst MateriaMed, Jinan 250062, Shandong, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
A variety of substituted 3-arylcoumarin derivatives were synthesised through microwave radiation heating. The method has characteristics of environmental friendliness, economy, simple separation, and purification process, less by-products and high reaction yield. Those 3-arylcoumarin derivatives were screened for antioxidant, alpha-glucosidase inhibitory and advanced glycation end-products (AGEs) formation inhibitory. Most compounds exhibited significant antioxidant and AGEs formation inhibitory activities. Anti-diabetic activity studies showed that compounds 11 and 17 were equipotent to the standard drug glibenclamide in vivo. According to the experimental results, the target compound 35 can be used as a lead compound for the development of new anti-diabetic drugs. The whole experiment showed that anti-diabetic activity is prevalent in 3-arylcoumarins, which added a new natural skeleton to the development of anti-diabetic active drugs.
COA of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Hu, YH; Wang, B; Yang, J; Liu, T; Sun, J; Wang, XJ or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles