An article Total synthesis and stereochemical revision of relgro and 10 ‘-oxorelgro WOS:000482917600021 published article about HYDROLYTIC KINETIC RESOLUTION; BETA-RESORCYLIC MACROLIDE; BIOLOGICAL EVALUATION; ACID LACTONES; HSP90; TRANSFORMATION; RADICICOL; KINASE in [Gaddam, Janardhan; Reddy, G. Sudhakar; Mohapatra, Debendra K.] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India; [Gaddam, Janardhan; Reddy, G. Sudhakar; Mohapatra, Debendra K.] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India; [Marumudi, Kanakaraju; Kunwar, Ajit C.] Indian Inst Chem Technol, CSIR, Ctr NMR & Struct Chem, Hyderabad 500007, Andhra Pradesh, India; [Yadav, Jhillu S.] Indrashil Univ, Sch Sci, Kadi 382740, Gujarat, India in 2019.0, Cited 57.0. Category: indole-building-block. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
The first asymmetric total synthesis and stereochemical assignments of 10-membered macrolactones relgro and 10 ‘-oxorelgro are disclosed. To this end, palladium-catalyzed Stille coupling, the Mitsunobu reaction, ring-closing metathesis, EDCI promoted coupling and the Jacobsen hydrolytic kinetic resolution are used as key steps. The total synthesis followed by thorough evaluation of the optical rotation and CD spectral data led to the revision of the absolute configuration at C-6 ‘ for both relgro and 10 ‘-oxorelgro. Moreover, the H-1 as well as C-13 NMR data are reported for the first time for relgro.
Category: indole-building-block. Welcome to talk about 100-51-6, If you have any questions, you can contact Gaddam, J; Reddy, GS; Marumudi, K; Kunwar, AC; Yadav, JS; Mohapatra, DK or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles