90858-86-9, 4-Bromo-5-methoxy-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
90858-86-9, NaH (60percent in oil, 75.6 mg, 3.15 mmol) is added to a RT solution of 4-bromo-5-methoxy-1 H-indole (500 mg, 2.1 mmol) in DMF (5 mL). The RM is stirred at RT for 20 min and iodomethane (0.145 mL, 2.31 mmol) is added. The RM is then stirred overnight at RT. Water is added, and the mixture is extracted twice with EtOAc. Combined organic layers are washed with brine, dried (MgSC>4), filtered and concentrated under reduced pressure. The residue is purified by FC (heptane:EtOAc, 1 :0 to 7:3), affording the title compound as a beige solid (426 mg, 84percent). LC-MS B: tR = 0.94 min; [M+H]+ = 241.91.
The synthetic route of 90858-86-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IDORSIA PHARMACEUTICALS LTD; BOSS, Christoph; CORMINBOEUF, Olivier; FRETZ, Heinz; LYOTHIER, Isabelle; POZZI, Davide; RICHARD-BILDSTEIN, Sylvia; SIENDT, Herve; SIFFERLEN, Thierry; (160 pag.)WO2018/210992; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles