Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Authors Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P in MDPI published article about in [Pitucha, Monika; Drozd, Monika] Med Univ Lublin, Fac Pharm, Independent Radiopharm Unit, PL-20093 Lublin, Poland; [Korga-Plewko, Agnieszka; Kubik, Joanna; Humeniuk, Ewelina; Adamczuk, Grzegorz] Med Univ Lublin, Fac Pharm, Independent Med Biol Unit, PL-20093 Lublin, Poland; [Czylkowska, Agnieszka; Rogalewicz, Bartlomiej] Lodz Univ Technol, Fac Chem, Inst Gen & Ecol Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Iwan, Magdalena] Med Univ Lublin, Fac Pharm, Chair & Dept Toxicol, PL-20093 Lublin, Poland; [Karczmarzyk, Zbigniew; Wysocki, Waldemar; Bartnik, Paulina] Siedlce Univ Nat Sci & Humanities, Fac Sci, 3 Maja 54, PL-08110 Siedlce, Poland; [Fornal, Emilia] Med Univ Lublin, Fac Med, Chair & Dept Pathophysiol, PL-20090 Lublin, Poland in 2021.0, Cited 50.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9
A series of thiosemicarbazone derivatives was prepared and their anti-tumor activity in vitro was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the synthesis pathway and assumed molecular structures of analyzed thiosemicarbazones. The conformational preferences of the thiosemicarbazone system were characterized using theoretical calculations by AM1 method. Selected compounds were converted into complexes of Cu (II) ions. The effect of complexing on anti-tumor activity has been investigated. The copper(II) complexes, with Schiff bases T1, T10, T12, T13, and T16 have been synthesized and characterized by chemical and elemental analysis, FTIR spectroscopy and TGA method. Thermal properties of coordination compounds were studied using TG-DTG techniques under dry air atmosphere. G361, A375, and SK-MEL-28 human melanoma cells and BJ human normal fibroblast cells were treated with tested compounds and their cytotoxicity was evaluated with MTT test. The compounds with the most promising anti-tumour activity were then selected and their cytotoxicity was verified with cell cycle analysis and apoptosis/necrosis detection. Additionally, DNA damages in the form of a basic sites presence and the expression of oxidative stress and DNA damage response genes were evaluated. The obtained results indicate that complexation of thiosemicarbazone derivatives with Cu (II) ions improves their antitumor activity against melanoma cells. The observed cytotoxic effect is associated with DNA damage and G2/M phase of cell cycle arrest as well as disorders of the antioxidant enzymes expression.
Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles