Name: 4-Methoxybenzaldehyde. Authors Wong, KT; Osman, H; Parumasivam, T; Supratman, U; Omar, MTC; Azmi, MN in MDPI published article about in [Wong, Kok Tong; Osman, Hasnah; Azmi, Mohamad Nurul] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia; [Parumasivam, Thaigarajan] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia; [Supratman, Unang] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, Indonesia; [Che Omar, Mohammad Tasyriq] Univ Sains Malaysia, Sch Distance Educ, Biol Sect, George Town 11800, Malaysia in 2021, Cited 37. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone derivatives with different types of semicarbazide. These compounds were characterized by IR, 1D-NMR (H-1, C-13 and Distortionless Enhancement by Polarization Transfer – DEPT-135) and 2D-NMR (COSY, HSQC and HMBC) as well as mass spectroscopy analysis (HRMS). The synthesized compounds were tested for their antituberculosis activity against Mycobacterium tuberculosis H37Ra in vitro. Based on this activity, compound 4a showed the most potent inhibitory activity, with a minimum inhibitory concentration (MIC) value of 17 mu M. In addition, six other synthesized compounds, 5a and 5c-5g, exhibited moderate activity, with MIC ranges between 60 mu M to 140 mu M. Compound 4a showed good bactericidal activity with a minimum bactericidal concentration (MBC) value of 34 mu M against Mycobacterium tuberculosis H37Ra. Molecular docking studies for compound 4a on alpha-sterol demethylase was done to understand and explore ligand-receptor interactions, and to hypothesize potential refinements for the compound.
Name: 4-Methoxybenzaldehyde. Welcome to talk about 123-11-5, If you have any questions, you can contact Wong, KT; Osman, H; Parumasivam, T; Supratman, U; Omar, MTC; Azmi, MN or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles