Quality Control of Mequinol. Alavi, SJ; Seyedi, SM; Saberi, S; Safdari, H; Eshghi, H; Sadeghian, H in [Alavi, Seyed Jamal; Safdari, Hadi; Sadeghian, Hamid] Mashhad Univ Med Sci, Sch Paramed Sci, Dept Lab Sci, Mashhad, Razavi Khorasan, Iran; [Seyedi, Seyed Mohammad; Eshghi, Hossein] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Razavi Khorasan, Iran; [Saberi, Satar] Farhangian Univ, Fac Sci, Dept Chem, Tehran, Iran; [Sadeghian, Hamid] Mashhad Univ Med Sci, Antimicrobial Resistance Res Ctr, Mashhad, Razavi Khorasan, Iran published Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors in 2021.0, Cited 29.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.
In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety andparasubstituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50= 0.88 and 0.80 mu M, respectively).
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles