An article Natural product-based design, synthesis and biological evaluation of 2 ‘,3,4,4 ‘-tetrahydrochalcone analogues as antivitiligo agents WOS:000469026400051 published article about OXIDATIVE STRESS; SUBSTANCE-P; MELANOGENESIS; PIGMENTATION; IMPAIRMENT; SKIN in [Zhong, Hui; Zhou, Jia; An, Xiao-Hong; Hua, Ying-Rong; Lai, Yi-Fan; Zhang, Rui; Ahmad, Owais; Shang, Jing] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China; [Zhang, Ye] Guilin Med Univ, Sch Pharm, Guilin 541004, Peoples R China; [Zhang, Ye] Guangxi Normal Univ, Sch Chem & Pharm, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China in 2019.0, Cited 38.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1-RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhong, H; Zhou, J; An, XH; Hua, YR; Lai, YF; Zhang, R; Ahmad, O; Zhang, Y; Shang, J or concate me.. HPLC of Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles