Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: Succinic acid, 110-15-6, Name is Succinic acid, SMILES is OC(=O)CCC(O)=O, belongs to indole-building-block compound. In a document, author is Zhu, Ming-Hui, introduce the new discover.
Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides
An efficient strategy for N/O-(deutero)alkylation of indoles and phenols with alkoxides/alcohols as the alkylation reagents is described. The consecutive detosylation/alkylation transformations feature mild reaction conditions, high ipso-selectivity, and good functional group tolerance (>50 examples). A one-pot selective N-alkylation of unprotected indoles with alcohols and TsCl is also realized. The application of this method is demonstrated by the introduction of isotope-labeled (CD3 and (CH3)-C-13) groups using the readily accessible labeled alcohols and the synthesis of pharmaceuticals.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 110-15-6. Name: Succinic acid.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles