In an article, author is Zhang, Nan, once mentioned the application of 132866-11-6, COA of Formula: C36H42ClN3O6, Name is Lercanidipine Hydrochloride, molecular formula is C36H42ClN3O6, molecular weight is 648.1882, MDL number is MFCD07773089, category is indole-building-block. Now introduce a scientific discovery about this category.
Direct Preparation of Indole Hemiaminals through Organocatalytic Nucleophilic Addition of Indole to Aldehydes
Hemiaminals are common in natural products as well as bio-active compounds. Hemiaminals with an indole moiety are particularly attractive due to the significant bioactivity of indoles. Herein, we reported an efficient organocatalyzed indole N-1 nucleophilic addition of alpha-oxoaldehydes to deliver various indole hemiaminals in good yields (up to 92%) and excellent regioselectivities with DABCO or triethylamine as the catalyst. The method is characterized by mild reaction conditions, widely available reagents, and general substrate scope, and it is also applicable to late-stage transformations without affecting the hemiaminal group. In addition, we carried out this reaction in an enantioselective fashion in good yields and high ee values with two general substrates.
If you are interested in 132866-11-6, you can contact me at any time and look forward to more communication. COA of Formula: C36H42ClN3O6.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles