A new application about 16096-33-6

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Related Products of 16096-33-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 16096-33-6, Name is 1-Phenyl-1H-indole,introducing its new discovery.

Indole was reacted with aryl electrophiles in the presence of 37% KF/Al2O3 and catalytic 18-crown-6 in DMSO at 120C to give selectively 1-arylindoles in fair to excellent yield. Electrophiles containing electronically unfavorable substitution patterns or leaving groups, such as 3-chlorobenzonitrile, coupled effectively under the reaction conditions.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles