COA of Formula: C7H5F3O. Recently I am researching about BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; MOLECULAR DOCKING; ANTICANCER ACTIVITY; PYRAZOLE; DESIGN; APOPTOSIS; POTENT; AGENTS; METASTASIS, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372135, 81302628, 21801139]; Postdoctoral Science Foundation (China)China Postdoctoral Science Foundation [2018T110533, 2016M590488]; Postdoctoral Science Foundation (Jiangsu Province) [1601136B]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20180942]; Project of Jiangsu Six Peaks of Talent [2014-SWYY-044, 2016-SWYY-CX’TD-008]; General Research Projects of Nantong City [MS2018-100]; Project of Jiangsu 333 high-level talents. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol
A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and exhibit good to excellent antitumor activities. Compound 10n has shown remarkable anticancer effect on SMMC-7721 cells (IC50 = 2.08 mu M), which is considerably lower than 5-FU (IC50 = 37.8 mu M) and similar to ADM (IC50 = 2.67 mu M), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that 10n also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-beta 1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, 10n also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. Our findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. (C) 2019 Elsevier Masson SAS. All rights reserved.
COA of Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles