In 2020.0 ORG BIOMOL CHEM published article about GALACTOSE-OXIDASE; ALCOHOL OXIDASE; ACTIVE-SITE; OXIDATION; PEROXIDASE; CHEMISTRY; CATALASE; ENZYME; ORDER in [Forget, Stephanie M.; Xia, Fan (Roderick); Hein, Jason E.; Brumer, Harry] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada; [Forget, Stephanie M.; Xia, Fan (Roderick); Brumer, Harry] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada in 2020.0, Cited 49.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Computed Properties of C7H8O
An Auxiliary Activity Family 5 (AA5) copper-radical alcohol oxidase (AlcOx) with promiscuous activity towards simple alkyl and aromatic alcohols was evaluated using real-time reaction progress monitoring. Reaction kinetics using variable time normalization analysis (VTNA) were determined from reaction progress curves. By this approach, a detailed view of the entire reaction time course under various conditions was obtained and used to identify parameters that will inform further process optimization development. Optimal activity was found impacted by several factors, including reaction pH, oxygen saturation, and the source of a co-oxidant, either HRP or a chemical alternative, potassium ferricyanide. Analysis of reaction progress curves demonstrated that reaction stalling occurred as a result of oxygen depletion and from a loss of enzyme activity over time. The cooperativity between AlcOx, horseradish peroxidase (HRP), and catalase that result in enhanced reactivity was explored, with reaction pH being identified as a key factor for optimal activity. The results show that a process with HRP is more robust than with potassium ferricyanide, but that both oxidants likely activate AlcOx by a similar mechanism. The phenomenon of product inhibition was investigated for representative reactants, revealing that reaction inhibition was more significant for butyraldehyde than for benzaldehyde. Our analysis suggests that this is linked to the greater proportion in which butyraldehyde exists in the hydrated form.
Computed Properties of C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Forget, SM; Xia, F; Hein, JE; Brumer, H or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles