The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane(SMILESS: C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1,cas:132098-59-0) is researched.SDS of cas: 12080-32-9. The article 《A chiral cage-like copper(I) catalyst for the highly enantioselective synthesis of 1,1-cyclopropane diesters》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:132098-59-0).
A facile cage-like chiral catalyst for the catalytic enantioselective cyclopropanation of multisubstituted olefins with phenyliodonium ylide malonate was developed. Remarkably, this newly designed and cheap bisoxazoline copper(I) complex resulted in the cyclopropanation of a range of substrates such as terminal, disubstituted, and trisubstituted olefins, giving the desired products in excellent yield (≤99%) with enantioselectivity (up to >99% ee). This protocol provides an efficient method for the synthesis of chiral 1,1-cyclopropane diesters. The single-crystal structure of a [Cu(MeCN)4]PF6 /bisoxazoline complex led to a proposed stereochem. model. The readily accessible starting material, cheap catalyst and high diastereo- and enantioselectivities make the present reaction potentially useful in organic synthesis.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles