Adak, Arup Kumar; Dutta, Basudeb; Manna, Saikat Kumar; Sinha, Chittaranjan published the artcile< Rhodamine-Appended Benzophenone Probe for Trace Quantity Detection of Pd2+ in Living Cells>, Quality Control of 950846-89-6, the main research area is rhodamine benzophenone palladium living cell.
Designing a fluorogenic probe for the determination of Pd2+ is a challenging anal. task. Pd2+ is a potentially toxic and harmful substance even at a very low level of contamination in the end product. Herein, a promising spirolactam-functionalized chemosensor, rhodamine-appended benzophenone (HBR), is designed and characterized by spectroscopic (1H NMR, 13C NMR, ESI-MS, and FT-IR) data along with the single-crystal x-ray diffraction technique. It acts as a highly sensitive and selective fluorogenic chemosensor for Pd2+ ions over other environmentally relevant cations in aqueous ethanol (1:1, volume/volume) at pH 7.4. The limit of detection (LOD) is 34 nM that is far below the WHO recommended Pd uptake (47μM). The plausible mechanism involves the specific binding of HBR with Pd2+ and the formation of 1:1 stoichiometry of the complex, which has been supported by ESI-MS, FT-IR data, Job plot, and association constant data (Benesi-Hildebrand plot). The computation study has been attempted to explain the ring cleavage fluorescence enhancement scheme of HBR upon binding with Pd2+. Furthermore, this “”turn-on”” probe has successfully applied to image the Pd2+ ion in cultured MDA-MB-231 cells.
ACS Omega published new progress about Fluorescence spectroscopy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Quality Control of 950846-89-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles