Adak, Arup Kumar; Purkait, Rakesh; Manna, Saikat Kumar; Ghosh, Bankim Chandra; Pathak, Sudipta; Sinha, Chittaranjan published the artcile< Fluorescence sensing and intracellular imaging of Pd2+ ions by a novel coumarinyl-rhodamine Schiff base>, Electric Literature of 950846-89-6, the main research area is coumarinyl rhodamine Schiff base fluorescence imaging Palladium ion.
Coumarinyl-rhodamine, HCR, served as an extremely selective sensor for Pd2+ ions in ethanol/H2O (8 : 2, volume/volume, HEPES buffer, pH 7.2) solution and the limit of detection (LOD) was 18.8 nM (3σ method). The free sensor, HCR, was weakly emissive and in the presence of Pd2+, the color changed from straw to pink with very strong emission at 598 nm in the presence of eighteen other cations. A plausible mechanism involved opening of the spirolactam ring of rhodamine on interaction with Pd2+, which was justified by structure optimization and transition energy calculations using the DFT technique. HCR underwent 1 : 1 complexation with Pd2+, which was confirmed via the Job’s plot, mass spectra and Benesi-Hildebrand plot (association constant Ka, 9.1 × 104 M-1). A sep. in vitro experiment showed that HCR could specifically sense Pd2+ in MCF7 (human breast adenocarcinoma) cell lines.
New Journal of Chemistry published new progress about Complexation. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Electric Literature of 950846-89-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles