Alen, J. published the artcileTetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structure-activity studies, Related Products of indole-building-block, the main research area is tetrahydropyrimidoindole preparation selective LIM kinase inhibitor SAR.
Extensive structure-activity studies on three different modification sites resulted in a series of LIM kinase inhibitors, containing a novel tricyclic hinge-binding motif based on the pyrrolopyrimidine scaffold. The compounds display a superior selectivity profile and significantly increased on-target activity compared to the former clin. candidate LX7101 (Lexicon Pharmaceuticals). Addnl., a soft drug approach to yield locally active analogs was successfully implemented.
MedChemComm published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 173458-87-2 belongs to class indole-building-block, name is 4-CHloro-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-B]Indole, and the molecular formula is C10H10ClN3, Related Products of indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles