On April 10, 2014, Ali, Amjad; Lo, Michael Man-Chu; Metzger, Edward; Yin, Lina; Hartmann, Rolf; Hu, Qingzhong; Heim, Ralf; Zimmer, Christina published a patent.Product Details of 52537-00-5 The title of the patent was Indoline compounds as aldosterone synthase inhibitors related applications. And the patent contained the following:
This invention relates to indoline compounds or their pharmaceutically acceptable salts, as defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Product Details of 52537-00-5
The Article related to aldosterone synthase inhibitor indoline preparation cardiovascular disease kidney failure, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Product Details of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles