COA of Formula: C8H8O2. In 2019.0 BIOORGAN MED CHEM published article about IRON SUPEROXIDE-DISMUTASE; TRYPANOSOMA-CRUZI INFECTION; CHAGAS-DISEASE; TRYPANOTHIONE REDUCTASE; BIOLOGICAL EVALUATION; DRUG DISCOVERY; ENERGY-METABOLISM; BENZNIDAZOLE; POSACONAZOLE; SALMONELLA in [Paucar, Rocio; Moreno-Viguri, Elsa; Perez-Silanes, Silvia] Univ Navarra, Inst Salud Trop, Dept Pharmaceut Technol & Chem, Pamplona 31008, Spain; [Martin-Escolano, Ruben; Marin, Clotilde; Sanchez-Moreno, Manuel] Univ Granada, Hosp Univ Granada, Dept Parasitol, Inst Invest Biosanitaria Ibs GRANADA, E-18071 Granada, Spain; [Azqueta, Amaya] Univ Navarra, Dept Pharmacol & Toxicol, Pamplona 31008, Spain; [Cirauqui, Nuria] Univ Fed Rio de Janeiro, Dept Pharmaceut Sci, BR-21949900 Rio De Janeiro, Brazil in 2019.0, Cited 95.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 were subjected to in vivo assays in a murine model. Both compounds caused a substantial decrease in parasitemia in the chronic phase, which was an even better result than that of the reference drug benznidazole. In addition, compound 9 also showed better antichagasic activity during the acute phase. Moreover, metabolite excretion, effect on mitochondrial membrane potential and the inhibition of superoxide dismutase (SOD) studies were also performed to identify their possible mechanism of action. Finally, docking studies proposed a binding mode of the Fe-SOD enzyme similar to our previous series, which validated our design strategy. Therefore, the results suggest that these compounds should be considered for further preclinical evaluation as antichagasic agents.
COA of Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles