Recently I am researching about HYDROXYAPATITE SCAFFOLDS; MECHANICAL-PROPERTIES; CERAMIC COMPONENTS; BONE REGENERATION; LOW-VISCOSITY; IN-VITRO; STEREOLITHOGRAPHY; GLASS; ENHANCEMENT; PERFORMANCE, Saw an article supported by the National Key Research and Development Program of China [2018YFB1105500]; Major Special Projects of Technological Innovation in Hubei Province [2019AAA002]; State Key Laboratory of Materials Processing and Die & Mould Technology for mechanical property tests. Published in ELSEVIER in AMSTERDAM ,Authors: Hua, SB; Su, J; Deng, ZL; Wu, JM; Cheng, LJ; Yuan, X; Chen, F; Zhu, H; Qi, DH; Xiao, J; Shi, YS. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol. Application In Synthesis of Mequinol
The porous bioceramic scaffolds require favorable mechanical properties and excellent bioactivity to promote bone repair. In this work, 45S5 bioglass (R) & biphasic calcium phosphate (BCP) bioceramic scaffolds with a diamond lattice structure (porosity of 70%) were manufactured accurately by digital light processing (DLP). After optimizing the solid loading of bioceramic suspension to 40 vol%, scaffolds with the minimum pore size of 400 mu m were fabricated successfully under exposure energy of 12.54 mJ/cm(2). In the initial stage of sintering, crystallization occurred during 45S5 bioglass (R) itself, bioglass also promoted hydroxyapatite (HA) decomposition to tricalcium phosphate (TCP). With extending holding time to 4 h, Si4+ from 45S5 bioglass (R) diffused into TCP to produce Ca-5(PO4)(2)SiO4, which could enhance the compressive strength of bioceramic scaffolds. Meanwhile, bioglass would assist the growth and roughening of ceramic grains because of the ion-diffusion from bioglass to BCP. However, as holding time extended to 6 h, abnormal grain growth and cracks occurred which would decrease compressive strength. The best value of compressive strength is 1.735 MPa at the holding time of 4 h. 45S5 bioglass (R) also accelerated ion exchange such as Si4+ and CO32- between bioceramic and SBF solution. This kind of bioceramics may be used as bioactive scaffolds with customizable fine structures and provide potential applications in bone tissue engineering.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles