An article Exploring the 2 ‘-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents WOS:000650694300001 published article about OXIDATIVE STRESS; CHALCONES in [Kostopoulou, Ioanna; Tzani, Andromachi; Polyzos, Nestor-Ioannis; Karadendrou, Maria-Anna; Detsi, Anastasia] Natl Tech Univ Athens, Sch Chem Engn, Dept Chem Sci, Lab Organ Chem, Heroon Polytechniou 9,Zografou Campus, Athens 15780, Greece; [Kritsi, Eftichia; Zoumpoulakis, Panagiotis] Natl Hellen Res Fdn, Inst Chem Biol, 48 Vas Constantinou Ave, Athens 11635, Greece; [Kritsi, Eftichia; Zoumpoulakis, Panagiotis] Univ West Attica, Dept Food Sci & Technol, Ag Spyridonos 12243, Egaleo, Greece; [Pontiki, Eleni; Liargkova, Thalia; Hadjipavlou-Litina, Dimitra] Aristotle Univ Thessaloniki, Sch Pharm, Lab Pharmaceut Chem, Fac Hlth Sci, Thessaloniki 54124, Greece in 2021.0, Cited 78.0. Name: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9
2 ‘-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) inhibitory activity, the design, synthesis, and bioactivity profile of a series of 2 ‘-hydroxy-chalcones bearing diverse substituents on rings A and B, are presented. Among all the synthesized derivatives, chalcone 4b, bearing two hydroxyl substituents on ring B, was found to possess the best combined activity (82.4% DPPH radical scavenging ability, 82.3% inhibition of lipid peroxidation, and satisfactory LOX inhibition value (IC50 = 70 mu M). Chalcone 3c, possessing a methoxymethylene substituent on ring A, and three methoxy groups on ring B, exhibited the most promising LOX inhibitory activity (IC50 = 45 mu M). A combination of in silico techniques were utilized in an effort to explore the crucial binding characteristics of the most active compound 3c and its analogue 3b, to LOX. A common H-bond interaction pattern, orienting the hydroxyl and carbonyl groups of the aromatic ring A towards Asp768 and Asn128, respectively, was observed. Regarding the analogue 3c, the bulky (-OMOM) group does not seem to participate in a direct binding, but it induces an orientation capable to form H-bonds between the methoxy groups of the aromatic ring B with Trp130 and Gly247.
Name: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kostopoulou, I; Tzani, A; Polyzos, NI; Karadendrou, MA; Kritsi, E; Pontiki, E; Liargkova, T; Hadjipavlou-Litina, D; Zoumpoulakis, P; Detsi, A or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles