With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1015460-59-9,7-Bromo-5H-pyrido[4,3-b]indole,as a common compound, the synthetic route is as follows.
Compound P (500 mg, 2.02 mmol), compound Q (655 mg, 2.23 mmol), NaHC03 (510 mg, 6.06 mmol), and Pd(dppf)2Cl2 (70 mg) in MeCN and H20 (4:1, 10 mL) were stirred at 90 C for 30 min. The reaction mixture was cooled to r.t., diluted with H20 (50 mL), and extracted with DCM (3 x 100 mL). The organics were combined and concentrated in vacuo. The resulting solid was washed with cold DCM (3 mL) to afford compound R as a white powder, which was used without further purification (340 mg, 1.02 mmol, 51 %). MS (ESI) m/z 334 (M+H)+, 1015460-59-9
1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael S.; HAGGARTY, Stephen J.; CAI, Quan; TELO BAPTISTA LIMA DA SILVA, Maria Catarina; ZHANG, Tinghu; FERGUSON, Fleur M.; (220 pag.)WO2019/14429; (2019); A1;,
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