1059630-08-8, (4aS,9bR)-Ethyl 6-bromo-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1 : To a degassed mixture of (4aS,9bR)-ethyl 6-bromo-3,4,4a,5-tetrahydro- lH-pyrido[4,3-b]indole-2(9bH)-carboxylate (1.60 g, 8.0 mmol), 2-chloro-2,2-di- deuteri oacetam i de (2.5 g, 26 mmol), and KI (2.68 g, l6mmol) in dioxane (30 mL), diisopropylethylamine (3.0 mL, 16 mmol) is added at room temperature. The reaction mixture is then heated to 104 C under vigorous stirring for 5 days. Solvents are removed under vacuum and the residue is suspended in dichloromethane (50 mL) and extracted with water (20 mL). The organic phase is separated, dried over anhydrous K2CO3 and (0280) concentrated to a residue. The product is purified by silica gel column chromatography using a gradient of 0 – 100% ethyl acetate in hexanes to obtain (4aS,9bR)-ethyl 5-(2-amino- 1 , 1 -di- 2-oxoethyl)-6-bromo-3,4,4a,5-tetrahydro-lH-pyrido[4,3-b]indole-2(9bH)-carboxylate as a brown oil (1.26 g, yield 41%). MS (ESI) m/z 384.1 [M+l]. The synthesis of the starting material is disclosed in US 2010/113781. The reaction scheme is shown below:
1059630-08-8, The synthetic route of 1059630-08-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; INTRA-CELLULAR THERAPIES, INC.; LI, Peng; ZHANG, Qiang; DAVIS, Robert; (63 pag.)WO2019/183341; (2019); A1;,
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